BRIC-IBSD Scientists discover molecule with anti-inflammatory activity from Mukthrubi : 11th nov25 ~ E-Pao! Headlines

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BRIC-IBSD Scientists discover molecule with anti-inflammatory activity from Mukthrubi
Source: The Sangai Express

Imphal, November 10 2025: BRIC-IBSD Scientist Dr Chingakham Brajakishor Singh, Scientist-E, and his research team recently discovered a molecule from Mukthrubi (local name) called as Zanthoxylumarmatum DC.

As per a release issued by IBSD, Mukthrubi (Z armatum) is used by the local people in making local delicacies as well as in tooth and gum related problems, rheumatism, etc.

The isolated bioactive molecule was identified as fargesinand checked for its anti-inflammatory activity against CpG-stimulated conventional type 1 dendritic cells by inhibiting IL 12 production.

Moreover, the phytocompound ferguson significantly inhibited the expression of CD80 in CpG-stimulated conventional type 1 dendritic cells.

The bioactive molecules were elucidated via single crystal X-ray crystallography, NMR and Mass spectrometry analysis.

The conventional type 1 dendritic cells (cDCl) are highly specialized and functionally critical subset of immune cells involved in the regulation of inflammation and antigen presentation and are central to immune homeostasis and disease pathogenesis.

As per IBSD, this is the first study to isolate and evaluate these specific lignans from Z armatum using bioassayfractionation strategy, and to investigate their in vitro effects on cDC 1 cells.

The research work was published in Frontiers in Pharmacology.

Dr Brajakishor and his team also have a patent on Anti-cancer composition from Mukthrubi.

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