TODAY -

MU researchers find anti-cancer compound in Shamba leaf
Source: Chronicle News Service

Imphal, July 02 2022: A research team of Manipur University has found a new anti-cancer drug compound in the leaves of Oroxylum indicum (Shamba) .

The research work was carried out jointly by Dr Asem Robinson Singh, Salam Asbin Singh, Naorem Tarundas Singh and Dr Thangjam Davis Singh, under the supervision of MU Department of Biotechnology Cancer and Molecular Biology Lab Prof Lisam Shanjukumar Singh.

Speaking to The People's Chronicle in this regard, Prof Shanjukumar informed that the research team had been screening the various plant species available in Manipur for the last 4-5 years.

The team used Bioassay Guided Isolation Technology for isolation and purification of compounds having anti-cancer compound.

The research gained momentum when the then MU administrator Jarnail Singh procured a Preparative-HPLC for the department.

Informing that more than 60 percent of the cancer drugs available today are either natural products or their derivatives; Prof Shanjukumar highlighted that Manipur is a promising geographical area with a rich assortment of flora and as such, there is the need to explore the natural products which can be used in medical science and other scientific applications.

He then said that over 300 plant species were examined, out of which some were found to have anti cancer compound.

These include Oroxylum indicum (locally known as Shamba and in Hindi, Sona Patha/Shyonak).

He added: "Oroxylum indicum is used in many countries, particularly in south-eastern region of Asia, for its medicinal properties.

As per reports, its usages are mostly limited to the stem bark, root and fruit.

In the Ayurvedic system, parts of this plant are used to treat burns owing to its inflammatory properties.

The MU research team, however, focussed on a more sustainable approach towards harvesting plant parts for medicinal use by employing the leaves of the plant to hunt for bioactive components.

The team went through an arduous task of bulk extraction of the leaves and fractionation of the extract into various parts based on their chemical and physical properties.

Each fraction was analysed for bioactivity.

The effort yielded few fractions that were promising and led to potential candidates for anticancer molecules.

Further purification and separation of the fractions into individual compounds were achieved by using HPLC.

"The use of a preparative-HPLC sped up the work as the team had been working on utilising the limited resources available in the lab to the maximum.

After successful purification of the compound, it was tested for its bioactivity using various molecular techniques and maintaining world-class standards in the experimental processes so as to evade any scepticism by reviewers and critics in the field.

The new compound is 2-[p-(2-Carboxy-hydrazino) phenoxy]-6-(hydroxymethyl) tetrahydro-2H- pyran-3,4,5-triol.A common name "Oroxyquinone" was given, taking the words "oroxy" from the scientific name of the plant, "Oroxylum indicum" and "quinone'' from the name of the chemical ring structure quinone containing in the chemical", he explained.

Stating that the new compound can induce one of the processes of natural cell death called "Apoptosis" in cancer cells of prostate cancer, lung cancer and cervical cancer; the professor pointed out that having the activity of causing cancer cell death is the main characteristic of anticancer drugs.

Prof Shanjukumar then said that the team found the molecular mechanisms for causing natural cell death were different in different cancer types.

In prostate cancer, the new compound causes the process of natural cell death via activation of a protein known as AIF (apoptosis-inducing factor), whereas in other cancers, it causes natural cell death via the caspase and PARP pathways.

At very low concentrations the new compound can prevent cancer metastasis in prostate cancer, he added.

Although there are various chemotherapeutic drugs available for clinical use today, hunt for novel and new compounds is ongoing and has shown tremendous interest of researchers across the globe.

This is mainly due to the fact that there have been incidences of relapse and severe outcomes of side effects associated with many of the drugs.

Nephrotoxicity, hepatotoxicity, etc., are among the few known side effects of synthetic chemotherapeutic drugs.

Moreover, negligible numbers of researches are focused on cancer metastasis, he conveyed.

Prof Shanjukumar continued: "Cancer metastasis is the leading cause of death in cancer patients and is associated with 90 percent of mortality.

Currently, there is no such drug that has the ability to prevent metastasis.

In addition, most of the researches are focused on elimination of cancer cells rather than localisation of the tumour and preventing metastasis.

The newly discovered molecule being anti-metastatic in nature may be a promising therapeutic candidate in future metastasis prevention and research".

Informing that the finding was published recently in one of the esteemed journals called 'Pharmaceuticals' published by MDPI, Switzerland, the professor stated that the finding was published after extensive peer reviews and scrutiny at MU.

Therefore, the authorities of the Institute should encourage quality publications and research-oriented work that will put MU among the top Institutes of India, he stressed.

He then informed that the team is going to undergo further research like pre-clinical using animal models and clinical trials on humans and collaborating with institutes within the state as well as outside, for developing the newly discovered compound as a drug for cancer treatment.

Prof Sanjukumar, however, strongly urged all concerned not to use the plant or the new compound as a drug before successful pre-clinical and clinical trial studies, as it may contain other toxic compounds.

He also informed that in one of their studies on Croton caudatus Geiseler, Miracle Plant of Saikot of Manipur, the department found the plant contained a compound, which enhances or aggravates lung cancer progression.


* Comments posted by users in this discussion thread and other parts of this site are opinions of the individuals posting them (whose user ID is displayed alongside) and not the views of e-pao.net. We strongly recommend that users exercise responsibility, sensitivity and caution over language while writing your opinions which will be seen and read by other users. Please read a complete Guideline on using comments on this website.




HEADLINES - 03, JUL 2022
  • Intensive search continues at tragedy site, 13 more bodies found to take death toll to 34
  • Ministerial team visits tragedy site
  • In a new high in last many days 7 new cases reported
  • Identify, deport foreigners : UCM
  • AMCO condoles
  • Drive against drugs to be held in Kshetrigao
  • Protection and Preservation Committee Manipur interacts with villagers
  • Auto driver dies in suspicious manner; JAC demands arrest of perpetrators within 48 hours
  • Inpi Chamber of Commerce inaugurated
  • Bamboo training centre inaugurated
  • Economic independence stressed
  • Kimneo Haokip Hangshing launches free EDS in CHC Saikul
  • International Day of Cooperatives observed
  • Week-long farmers training programme concludes at Chingjaroi
  • Workshop / production concludes
  • LPG cylinders and stoves distributed
  • DM College of Teacher Education claims
  • 13 more bodies found on Day 3, 28 still missing
  • Don't venture near Ijei River: Noney DC
  • MARSAC expert fears more natural disasters
  • NEP 2020 implementation underway: MoS Dr Subhas
  • Mixed response to SUP ban
  • Rescue Op to continue till all bodies found: Susindro
  • State reports seven new cases
  • Will draft Manipur Indigenous People's Bill: IPFM
  • MLA Kimneo stresses on early diagnosis
  • Convention opposing Agnipath Scheme held
  • Senapati celebrates Vanamahotsav, saplings planted
  • 3rd Manipur folk song festival celebrated
  • MDA, Gorkha bodies provide relief items
  • No shortage of urea for Wabagai AC farmers: MLA
  • Nemcha stresses policy to spur industrial development
  • Saikot MLA distributes planting materials
  • Dengue positive cases in Moreh reach 22
  • Tobacco use origin of drug abuse: Dr Ranibala
  • Kuki body hands over relief items for rescue workers
  • Foundation calls for setting up Heritage Park at Keibul Lamjao
  • Andro AC shutdown warned over urea issue
  • Application called for National Bravery Award, 2022
  • Body against transfer of commando OC
  • NPF Chandel new members take oath
  • Yumnam Khunou community hall inaugurated
  • Slopeland not first to get NAAC accreditation: DMTCE
  • RNYOM seeks SDRF units in Noney, Tamenglong
  • ACOAM Lup celebrates 22nd foundation day
  • Rahman JAC warns of intense protest
  • LATEST IN E-PAO.NET
  • Bike Rally - Sekmai to Kangla : Gallery
  • Violence in Manipur 2023-2024 : Timeline
  • 'Modi must announce finality of Naga pacts'
  • Gliding over Brahmaputra
  • Question leaks cause stress among student
  • Home remedies for prickly heat
  • After IIT, AIIMS it is now IIM
  • Stealing spotlight from Manipur crisis
  • Tarpon chaklen katpa @ Andro #2 : Gallery
  • Strongly condemns violence in Jiribam
  • Lessons from outcome of LS election
  • Tumcho releases "Goodness of God"
  • Right diagnostic for antimicrobial resistance
  • 12th June is World Day against Child Labour
  • Hands of geo-politics ?
  • The row over NEET-2014
  • 2nd Annual Art Exhibition #1 : Gallery
  • Chilli Chicken: Film Spotlighting NE in B'lore
  • Committee of Narcotics Anonymous - Imphal
  • The Power of Meditation
  • Oceans as a career choice
  • Getting more and more audacious
  • A test of leadership
  • Education Fair @Imphal #2 : Gallery
  • Gifting two seats to Cong
  • Voters empowered democracy
  • Postcards from Meghalaya premieres
  • Milk : Essential nutrient for a healthy body
  • Failing in competitive exam not end of world
  • Delhi : A mere spectator
  • Abandoning Jiribam
  • Birth Centenary of Jananeta Irabat, 1996 : #5
  • Ima Keithel flood- May 30 #2 : Gallery
  • Mainstream in Shoes of Alternative
  • Protect the medicines that protect us
  • Lets take action for our land & our future
  • Democracy and independent media
  • Agenda at work to shut Western Gate
  • Keeping Manipur on the boil
  • Descent of Radha-Krishna #34: Download
  • The Enigmatic Journey of 'Laikhutshangbi'
  • Individual and the Social
  • An Ardent Appeal to All Concerns
  • Condemnation of Attack & Govt Inaction
  • The Power of Poppy - 34 :: Poem
  • Scientist of Manipur: Laishram Shanta
  • Alien fishes spotted in Manipur's rivers
  • Training on mushroom at Langthabal
  • Digital avatars or deepfakes ?
  • 7th June is the World Food Safety Day
  • How to prepare for UPSC after 10th ?
  • The Jiri violence
  • Beginning of a new vote culture ?
  • Bimol Akoijam (Cong) wins Inner PC : Gallery
  • BJP, NPF & other NDA pay heavy price
  • Nature is one of greatest blessings of God
  • Plantation drive in Tripura, Assam & Manipur
  • Summer beauty
  • Environment conservation & over-exploitation
  • Is Modi cut out for leading a coalition ?
  • 'Ishanou' Selection @ Cannes #2: Gallery
  • Scholarship for Johnstone Hr Sec students
  • 1st foundation day of Interfaith Forum
  • World Environment Day: Our land, our future
  • Indonesia stronger anti-tobacco measures
  • Navigating a fragile Myanmar: India's policy
  • New breed entering electoral politics
  • The road to formation of new govt
  • International Dance Day #1 : Gallery
  • Matchbox marketing mantra
  • Stop harming nature :: Poem
  • Saving for oneself & the Nation
  • Model United Nations (MUN) conducted
  • Tobacco: Threat to health & environment
  • Candidate from ruling party biting the dust
  • The verdict
  • Birth Centenary of Jananeta Irabat, 1996 : #4
  • Imphal valley districts flooded #3 : Gallery
  • Navigating Remal amidst Manipur conflict
  • We are #GenerationRestoration
  • Intl Day of Innocent Children Victims
  • Apparel Industry Skills & Innovation CoE
  • What's in a cyclone's name ?
  • Ongoing clash, the floods, the losses
  • Exit poll predictions
  • Descent of Radha-Krishna #33: Download
  • Evading flood & rethinking urbanization
  • Manipur Flood: Health Advisory
  • Onus on civil bodies to ensure NNPG unity
  • Rats also cause flood
  • Benefits of JEE Main mock tests
  • People have spoken, now the results
  • The fury of Remal
  • Ima Keithel flood- May 30 #1 : Gallery
  • The flood in our Stars
  • The Power of Poppy - 33 :: Poem
  • 'Group of people misrepresented themselves'
  • EV industry and career options
  • Scientist of Manipur: Chandrakant Aribam
  • Candy flavoured traps to hook next Gen
  • Commemorate Naga Plesbicite Day 1951 #2
  • Tobacco affects health & environment too
  • Jio extend validity for Customer in Manipur
  • Students must learn about AI irrespective
  • As vote count day approaches : Floods
  • Imphal valley districts flooded #2 : Gallery
  • Flooded : Sacrifice of Yairipok's Maiden
  • World No Tobacco Day 2024
  • Chandam Rishikanta wins NPC Nat'l C'ship
  • Flood: Helpline numbers for emergency
  • Battling body odour ?
  • Floods : Not entirely natural phenomena
  • PM Modi's purpose
  • Imphal valley districts flooded #1 : Gallery
  • June Calendar for Year 2024 : Tools
  • Flood: Control Rooms & Helpline numbers
  • Economic impact of ongoing conflict
  • Army Recruitment Rally for Manipur
  • Cut deficit, boom likely
  • Are Gods angry ? Wake up call for Manipur
  • Beating of the Retreat #2 : Gallery
  • We did Overcome: Mayhem of Month of May
  • Training on mushroom at Potshagbam
  • Famous female Mathematicians in India
  • Disinformation campaign thengnare
  • Human trafficking puts humanity to shame
  • Sky opens up in all its fury
  • Licypriya meets Italy PM & Pope Francis
  • HSLC (Class X) 2024 : Full Result
  • HSLC 2024 : Important Info & Grading System
  • HSLC 2024 : Pass % : Private Schools
  • HSLC 2024 : Pass % : Aided Schools
  • HSLC 2024 : Pass % : Govt Schools
  • HSLC 2024 : Statistical Abstract
  • HSLC 2024 : Comparative Statement
  • Combined Defence Services Exam 2024
  • Good show in Class X exams
  • Downplaying the crisis
  • Birth Centenary of Jananeta Irabat, 1996 : #3
  • Reviving Lamphelpat : Conservation : Gallery
  • Commemorate Naga Plesbicite Day 1951 #1
  • "ST status for Meetei" at Hojai
  • The Power of Poppy - 32 :: Poem
  • Insights from CUET-UG Counselling
  • International Day for Biological Diversity
  • Unseen force at work: Time to unravel it
  • Sheikh Hasina's revelation
  • The Vanishing Meitei Tribe
  • Building career in defence & strategic study
  • Why example of model code of conduct ?
  • Ownership of responsibility
  • Will pressure mount on key players in NE
  • How to save your foot after an accident
  • Children Camp @JNMDA Imphal #3 : Gallery
  • Education Fair @Imphal #1 : Gallery
  • Project Associate @ CSE, Assam Univ
  • Understanding schizophrenia
  • Advancement in Multi Objective Optimization
  • When will women in voter list increase ?
  • Making 2 plus 2 is equal to 5
  • Changing face of drug menace
  • Scientist of Manipur: Jayanta Manoharmayum
  • 25 yrs since Atal Vajpayee visit to RIMS
  • 4 Lakhs donated to support (L) Maipak Family
  • Clarification: Guwahati Meet on Humanitarian
  • Start UPSC prep after 12th for success
  • Tips to avoid melting makeup in summer
  • Giving a big solid push to ST demand
  • Time to come clean
  • Sajibu Cheiraoba: 1 occasion, 2 narratives #3
  • Khongjom Day @Khebaching #2 : Gallery
  • A year of hostilities
  • Licypriya Kangujam to travel to Italy
  • Declining moral standards in public life
  • Healthy democracy with independent media
  • Why endangered species matter to us
  • Significant Guwahati meeting : 1st visible step
  • The Pallel story
  • Aftermath of ferocious hailstorm #2 : Gallery
  • Ukhrul: Climate change grip on water supply
  • Commemoration of World Eld's Deer Day
  • Indo-Naga Talks (From 2012) :: Timeline
  • "ST status for Meetei" at Hiyanglam
  • Dance of democracy, a miracle in making !
  • Learn to look 10/20/30 years hence
  • The zero FIR, zero lesson
  • 'Ishanou' Selection @ Cannes #1: Gallery
  • MOU signed: MTI-HUB & KIIT-TBI & SAbF
  • Lament of the Mourning Choir :: Poem
  • "ST status for Meetei" at Wabagai
  • RSS-BJP fracas
  • Trials for Canoe Slalom World Cup
  • Poser from a villager says it all Kamjong
  • The cover-up effort
  • Birth Centenary of Jananeta Irabat, 1996 : #2
  • Manipuri women in the arena of politics
  • "ST status for Meetei" at Assam
  • Aimee Baruah at red carpet of Cannes
  • National Defence Academy Exam 2024
  • How digital media changed communications
  • Manipur stands scandalised
  • All eyes on UP battle
  • Descent of Radha-Krishna #32: Download
  • Riots to a shrine- Ram Mandir of Ayodhya
  • Handle with care. F.R.I.E.N.D.S inside!
  • The Power of Poppy - 31 :: Poem
  • Celebrate the journey !
  • Career counselling : A life guidance tool
  • Scientist of Manipur: Amom Ruhikanta
  • Preserving Thang-Ta :: Rare Photos
  • Regarding Human Rights Situation in Manipur
  • Malemnganbi Laishram : Science Topper
  • Featured Front Page Photo 2024 #2: Gallery
  • Thokchom Sheityajit : Arts Topper
  • Aiena Naorem : Commerce Topper
  • AISSE 2024 Exam Result- RKM Imphal
  • Gold, new world currency !
  • Milk for hair and skin
  • Of illegal immigrants & the larger picture
  • The missive from Kamjong
  • Hr Secondary Exam 2024 : Science Topper
  • HSE 2024 : Subject Pass Percentage
  • HSE 2024 : District Pass Percentage
  • HSE 2024 : Candidates with Highest Marks
  • Hr Secondary Exam 2024: Science Full Result
  • Hr Secondary Exam 2024: Arts Full Result
  • Hr Secondary Exam 2024: Commerce Result
  • Hr Secondary Exam 2024 : Arts Topper
  • Hr Secondary Exam 2024 : Commerce Topper
  • World Bamboo Congress @Taiwan : Gallery
  • Aftermath of ferocious hailstorm #1 : Gallery
  • Radio E-pao: Manipuri Film OST (130+ song)
  • Cheirao-chingkaba @ Chinga : Gallery
  • Nupi Landa Thaunaphabishing : Full Book
  • A ferocious hailstorm @Imphal : Gallery
  • '365 Days of Chin-Kuki Aggression' : Gallery
  • Athoubasingi Numit #2 : Gallery
  • National Science Teacher workshop
  • Sajibu Cheiraoba Chak Katpa #2 : Gallery
  • Scientists of Manipur : Ngangkham Nimai
  • Kenedy Khuman (Singer) : Gallery
  • GHOST of PEACE :: Download Booklet
  • List of Kings of Manipur: 33 - 1984 AD