TODAY -

MDR-TB treatment regimen: Short indeed is beautiful

Shobha Shukla *

MDR-TB treatment regimen: Short indeed is beautiful



WHO recently announced new recommendations to speed up diagnosis and improve treatment outcomes for multi drug resistant TB (MDR-TB) through the use of a novel rapid diagnostic test called MTBDRsl, and a shorter, cheaper 9-12 month treatment regimen. The new treatment regimen can be completed in 9-12 months— less than half the time required by the current 24-month treatment standard used worldwide.

Costing less than $1000 per patient, this new regimen is not only much less expensive than the current standard regimen, but it also reduces the duration of treatment by 12 to 15 months. It is expected to dramatically improve the current low cure rate and potentially decrease deaths due to better adherence to treatment and reduced loss to follow-up.

MDR-TB is defined as TB that is resistant to at least rifampicin and isoniazid—the two most effective drugs for treating drug sensitive TB. Resistance generally stems from inadequate treatment or improper use of medicines. MDR-TB can also spread directly from one person to another. MDR-TB is difficult and expensive to treat, and can also be fatal. According to WHO’s Global TB Report of 2015, 5% of all global TB cases are of MDR-TB. This translates into 480,000 cases every year. Only 25% of these are detected and put on treatment, and only 50% of those treated are cured.

In a recent webinar organised by CNS (Citizen News Service) on this important issue (see recording: www.bit.ly/june16-recording ), Dr Fuad Mirzayev, Medical Officer at the WHO Global TB Programme, clearly spelled out the WHO recommendation— “A shorter MDR-TB regimen of 9-12 months may be used instead of the conventional regimen in adults, PLHIV and children with rifampicin resistant TB (regardless if isoniazid resistance is confirmed or not), who have not been previously treated with 2nd line drugs and in whom resistance to fluoroquinolone and 2nd line injectable agents has been excluded or is considered highly unlikely, It is NOT recommended for patients with 2nd line drug resistance, or with extra pulmonary TB, or for pregnant women. In such cases individualised conventional MDR-TB regimens should be used.”

To rule out resistance to second-line drugs—a critical prerequisite for eligibility of MDR-TB patients for the shorter regimen, WHO recommends the rapid diagnostic test MTBDRsl that gives results in just 24-48 hours. This DNA-based LPA (line probe assay) identifies genetic mutations in MDR-TB strains, that make them resistant to fluoroquinolones and injectable second-line TB drugs.

Evidence review for shorter MDR-TB regimen was based on meta-analysis of results of initial programmatic studies conducted by The Union, Damien Foundation, Médecins Sans Frontières (MSF) and the Antwerp Institute of Tropical Medicine in Belgium, involving 1205 patients with uncomplicated MDR-TB. Data for 515 patients under the Damien Foundation pilot programme, using a 9 month treatment regimen in Bangladesh, shows a cure rate of 82.1% and overall success rate of 84.5%.

This study was followed by the Union coordinated first multi-country MDR-TB patient cohort study of 1000 patients in 9 countries of West Africa (Benin, Burkina-Faso, Burundi, Cameroon, Côte d’Ivoire, Central African Republic, Niger, Democratic Republic of Congo and Rwanda), treated with a modified Bangladesh regimen. Dr ID Rusen, Senior Vice President, International Union Against TB and Lung Disease (The Union), shared that, “Interim analysis of 408 patients has demonstrated 82.1% treatment success rate, demonstrating that the 9 month regimen can be successful in other environments than Bangladesh, and also in settings with high HIV prevalence”.

Currently on going is the Union-sponsored and USAID supported STREAM study (Standardised Treatment Regimen of Anti-TB Drugs for Patients with MDR-TB) to evaluate other shortened regimens for patients with MDR-TB. STREAM Stage 1 study has been ongoing in Ethiopia, South Africa, Vietnam and Mongolia, and results are expected in 1st quarter of 2018.

STREAM has recently expanded to test two additional shortened treatment regimens using bedaquiline, a new medicine produced by Janssen Pharmaceuticals. This expanded arm will evaluate a 9 month all–oral regimen, that does not require painful injections, and an even shorter simplified 6-month regimen.

This STREAM Stage 2 study envisages to enroll 1155 patients in at least 10 countries by end of 3rd quarter of 2018 and initial end point results expected in 3rd quarter of 2020, informed Rusen. WHO’s recommendation will have profound implications for countries like India that are beset with the epidemic of MDR-TB. The adoption of a shortened regimen will not only reduce the burden on patients and on healthcare systems, but also improve cure rates.

Dr Sunil Khaparde, Deputy Director General of Revised National TB Control Programme, Ministry of Health and Family Welfare, India, conceded that India has the highest TB burden (2.2 million cases every year) and highest MDR-TB burden also with 72,000 MDR-TB cases every year and only 28,000 of these are treated. He said that the new shortened regimen holds a lot of promise and will be more rational and cost effective for India.

“The conventional treatment takes at least 18-24 months to complete and has only 50% cure rate. Patients find it difficult to take the very toxic 2nd line drugs for such a long period. This prolonged treatment period creates adherence problems and often results in treatment interruption and loss to follow up. The new regimen will definitely improve adherence and hence cure rate,” he said.

Although formal clinical study for the shorter regimen has not been conducted in India, but Khaparde assured that very soon the proposal for roll out of this new regimen will be put up before the expert committee. José Luis Castro, Executive Director at The Union, has rightly remarked that, “Statistics clearly show that MDR-TB is an increasing burden and much of this is due to a failure of basic TB control.

The international TB community must advocate for investment in the expansion of quality basic services and preventative care on the frontline where it matters most. The onus is on us all to ensure that access to correct treatments, both for patients and health care providers, increases exponentially.” Countries need to move quickly to implement the new regimen by formally incorporating it into their national TB guidelines.

Accurate and early diagnosis along with shorter, cheaper and more effective treatment can help countries deliver on their promises to end TB by 2030 or earlier as envisaged in Sustainable Development Goal 3.3.


* Shobha Shukla, Citizen News Service – CNS , wrote this article for e-pao.net
Shobha Shukla is the Managing Editor at Citizen News Service (CNS) and has reported on global health related issues consistently for decades. Follow her on Twitter: @CNS_Health
This article was webcasted on July 10, 2016.



* Comments posted by users in this discussion thread and other parts of this site are opinions of the individuals posting them (whose user ID is displayed alongside) and not the views of e-pao.net. We strongly recommend that users exercise responsibility, sensitivity and caution over language while writing your opinions which will be seen and read by other users. Please read a complete Guideline on using comments on this website.




LATEST IN E-PAO.NET
  • Colonial Knowledge Production in NE #7
  • Violence in Manipur 2023-2025 : Timeline
  • Make Yourself Visible to Opportunity
  • Orange bowl: tradition with ecological wisdom
  • 10 ways to keep a kitchen garden disease free
  • Between PR, military mandates & AFSPA
  • Allocation fund for MLALAD Fund during PR
  • Denounces Killing of KNA Deputy C-in-C
  • COVID-19: Update 03 July 2025 : Manipur
  • Cases of fake Aadhaar cards
  • Sincere dealing must for stricter Aadhaar
  • Archaeology: Culture of Manipur : Booklet
  • Wanna be a singer? Get Botox
  • A Central institute in Manipur
  • Nagging in the name of love
  • COVID-19: Update 02 July 2025 : Manipur
  • 'Benefits' of Indira's Emergency
  • Social Stigma :: Poem
  • Inking a peace pact: Why, how: SoO quagmire
  • Van Mahotsav under shadow of declining forest
  • 11th Th Kishan Memorial Lecture : Gallery
  • Shinthoibi, Jangvei, Tamphaton : eMing
  • Manipur crisis & the Left media's blind spot
  • COVID-19: Update 01 July 2025 : Manipur
  • Bombom RK : Musclemania Universe NYC
  • The Grief :: Poem
  • Music Concert & Quiz (MCQ) 2.0
  • SoO agreement unlikely to be scrapped
  • Regulating use of plastic carry bags
  • Mera Houchongba @Kangla #4 : Gallery
  • International Day of Yoga @JNMDA : Gallery
  • BD Behring: The inimitable Gentleman I knew
  • Violence in the name of patriotism : Misguided
  • Daily oral vs long-acting injectable for HIV
  • COVID-19: Update 30 June 2025 : Manipur
  • Smile :: Poem
  • Why was President's Rule imposed ?
  • BJP under pressure to forge unity
  • Kang @Leikai in Imphal : Gallery
  • July Calendar for Year 2025 : Tools
  • COVID-19 : A recurring crisis in Manipur
  • DC Kaith and Forestry in Manipur : Book
  • COVID-19: Update 29 June 2025 : Manipur
  • Longing for Peace :: Poem
  • Black badge, slogan protest by peeved scribes
  • Present the true picture before Delhi
  • Pung-Cholom @ Polo Tournament : Gallery
  • Life: A Journey Through Thought & Being
  • Khongjai Hills & Kuki claim to indigeneity
  • Master Time by Managing Information
  • COVID-19: Update 28 June 2025 : Manipur
  • Pride & patriotism in CCpur's army families
  • The Power of Poppy - 87 :: Poem
  • World Decarbonisation Day: green environment
  • Welcome Home - Nganthoi #2 : Gallery
  • Loss of two precious lives from Manipur
  • Balancing civil liberties with public safety
  • COVID-19: Update 27 June 2025 : Manipur
  • Gender equality & human rights are indivisible
  • Stay hydrated this summer season
  • Silent Half of the Sun :: Poem
  • Connecting the dots in the wishlist
  • Assembly record tampering claims by ex-CM
  • The immortal legacy of Pukhramba Kajao
  • International Day against Drug Abuse 2025
  • COVID-19: Update 26 June 2025 : Manipur
  • Black pottery from Ukhrul - tribal heritage
  • Program on "Mission-Drug Free Campus"
  • Play makes a better world
  • Urgent Appeal to the Honourable MLAs
  • Tribal Empowerment Campaign at CCpur
  • Talk doing the round: PM to come
  • 'Emergency' relief for under-fire BJP
  • Golden Jubilee Art Fair @Imphal : Gallery
  • Declaration: Meetei People Convention, Delhi
  • A Flower Among the Rocks :: Review
  • Book Donation Campaign
  • Improved road connectivity boosts livelihoods
  • To Have Great Dreams :: Poem
  • COVID-19: Update 25 June 2025 : Manipur
  • Regret vs Sorry: Technical & moral insight
  • Cocktail of inept Govt, selfish people
  • State trailing others in cleanliness
  • Colonial Knowledge in NE India #6
  • UHI effect & rising temperatures in Manipur
  • Frequent road blockades cripple economy
  • COVID-19: Update 24 June 2025 : Manipur
  • Unite Health with Community health services
  • NSU, Imphal, tops IIRF Ranking 2025
  • Endless conflict :: Poem
  • Pak nobel pish prize for Trump
  • May 3, 2023 - June 24, 2025: Failure of Delhi
  • Hotter days, sudden rainfall no more a rarity
  • "The Great June Uprising" #2 : Gallery
  • How to Build a Career, Lead with Purpose
  • 2nd Foundation Day- Karnataka Meitei Assn
  • COVID-19: Update 23 June 2025 : Manipur
  • NSCN-IM Amnesty threatens to isolate it
  • Sunset :: Poem
  • Intl Yoga Day for a healthier environment
  • Of clogged drains and plastics
  • Poor roads testify Govt indifference
  • Welcome Home - Nganthoi #1 : Gallery
  • The Silent Erosion of Manipuri Language
  • Design health services around people
  • Serene Hills Host Inspiring Int'l Yoga Day
  • COVID-19: Update 22 June 2025 : Manipur
  • Chopper services between Senapati & Imphal
  • High Court Judges interacted with convicts
  • Redyeing the Fabric :: Poem
  • Differences yet to be resolved stand
  • Border fencing rage as solution eludes
  • Radio E-pao: 14 new songs updated
  • Climate Adaptive Agroforestry
  • Manipur overlooked demographic shifts
  • Young designers shine on Fashion Stage
  • COVID-19: Update 21 June 2025 : Manipur
  • International Day of Yoga at Lamphelpat
  • International Day of Yoga at JNMDA
  • The Power of Poppy - 86 :: Poem
  • Keishampat Lairembi Haraoba #1 : Gallery
  • Crisis in Manipur's Contemporary Education
  • Best 8 Performances in Manipuri Cinema
  • Identity: Caught between China & India ?
  • COVID-19: Update 20 June 2025 : Manipur
  • To The Father Who Listens :: Poem
  • How does net suspension affect youths ?
  • Targeting farmers to cripple state's economy
  • The virus is back and spreading
  • Who is afraid of Manipur ?
  • A threatened lily growing at Shirui Hills
  • World Environment Day in Manipur : Gallery
  • Ambubachi Mela at Maa Kamakhya
  • COVID-19: Update 19 June 2025 : Manipur
  • Dolls made from repurposed vegetable refuse
  • Condemns Attack on Farmer & Killing
  • Abhorrent politics of SoO
  • Police arrogance on harmless drivers
  • "The Great June Uprising" #1 : Gallery
  • Solution from Buddhist & Jain perspectives
  • AI sparks employment concerns in Manipur
  • Greatest Foe :: Poem
  • Chief Justice at Relief Camp, Kangpokpi
  • Call for Recognition of a 3rd Category of IDPs
  • Jun 18, 2001- May 3, 2023: Seed of violence
  • Contract scam in hill districts
  • Colonial Knowledge in NE India #5
  • Spaced Out - Panthung Di Kadaaida! : Rvw
  • Condemns the Killing of Abdul Qadir
  • COVID-19: Update 17 June 2025 : Manipur
  • Thoubal aspirant makes Manipur proud
  • Tamenglong hospital brings quality healthcare
  • Chief Justice at Relief Camp, Mayang Imphal
  • Kuki CM & Sixth Schedule
  • Selective protests, selective silence
  • Nailing the culprits need of the hour
  • UK Meetei diaspora run for Myanmar : Gallery
  • Erwin Khundrakpam : NEET-UG 2025 topper
  • Will we rise to #endAIDS challenge or stumble
  • COVID-19: Update 16 June 2025 : Manipur
  • Appeal to Prime Minister: Manipur Crisis
  • Urges Action on Misinformation
  • Condolences : 2 young cabin crew
  • Grateful To Be Alive :: Poem
  • Making bonfire on the roads
  • Aggression yet again, inspite of playing victim
  • Aftermath of flooding @ Khurai #2 : Gallery
  • Zomia, geopolitics, & the struggle for unity
  • COVID-19: Update 15 June 2025 : Manipur
  • Condolences : Demise of 2 Manipuri Girls
  • Manipur unites in grief after Air India tragedy
  • Hail arms recovery as step toward peace
  • Cleanliness Drive at JNIMS Campus
  • Global Wind Day for a clean environment
  • First came the rain, then the heat
  • Rise in Covid-19 cases
  • Thang-Ta Day @Khuman Lampak #3 : Gallery
  • Meetei diaspora in UK runs for Myanmar victim
  • Manipur empower children with disabilities
  • COVID-19: Update 14 June 2025 : Manipur
  • World Blood Donor Day 2025
  • The Power of Poppy - 85 :: Poem
  • A Northeast Gin Makes Its Mark
  • Mera Houchongba @Kangla #3 : Gallery
  • Saluting Nganthoi, Lamnunthem : Joining hand
  • Condolence : Nganthoi & Lamnunthem
  • 50 years of Pebet #2 : Gallery
  • Indo-Naga Talks (From 2012) :: Timeline
  • Colonial Knowledge in NE India #4
  • Namphake Monastery @ Dibrugarh : Gallery
  • Protest @Checkon -AT arrest [Jun 9] : Gallery
  • Protests - AT arrest [Jun 8 night] : Gallery
  • Aftermath of flooding @ Khurai #1 : Gallery
  • /li>
  • Flooding at JNIMS Hospital #2 : Gallery
  • North East NSS Festival @ MU : Gallery
  • 27th Meira Paibi Numit : Gallery
  • Trump's tariff legacy & its global echo
  • Flooding at JNIMS Hospital #1 : Gallery
  • Flooding Imphal East [31 May] #3 : Gallery
  • Flooding Imphal East [31 May] #2 : Gallery
  • Flooding Imphal East [31 May] #1 : Gallery
  • S Nirupama @Miss Universe : Gallery
  • Protesters to Raj Bhavan [May 25]: Gallery
  • Human Chain @Airport road [May 26]: Gallery
  • Miss Shirui Pageant Contestant: Gallery
  • 48 hrs Bandh: protest security forces: Gallery
  • Protest Rally: Journalist harassment: Gallery
  • HSLC 2025: Full Result (Check Roll No)
  • HSLC 2025: Important Info & Grading System
  • HSLC 2025 : Compartmental candidates
  • HSLC 2025 : Comparative Statement
  • HSLC 2025 : Statistical Abstract
  • HSLC 2025 : District Pass Percentage
  • HSLC 2025 : Govt School Pass %
  • HSLC 2025 : Aided School Pass %
  • HSLC 2025 : Private School Pass %
  • People's Convention on 3rd May #2 : Gallery
  • Featured Front Page Photo 2025 #2: Gallery
  • Riya Khwairakpam : HSE Science Topper
  • Keisham Hannah : HSE Arts Topper
  • Warepam Lidia : HSE Commerce Topper
  • HSE 2025 Result : Science Full Result
  • HSE 2025 Result : Arts Full Result
  • HSE 2025 Result : Commerce Full Result
  • HSE 2025 Information / Abbreviation
  • HSE 2025 Topper : Science
  • HSE 2025 Topper : Arts
  • HSE 2025 Topper : Commerce
  • HSE 2025 : Pass Percentage
  • HSE 2025 : Result Abstract
  • HSE 2025 : Candidates with Highest Marks
  • Ougri Lirol :: Part 1 : Ooba Video
  • President's Rule in Manipur : 1967 - 2025
  • Downloadable Manipuri Calendar :: 2025